The present study focuses on understanding the reasons for immune dysfunction in lung cancer (LC) patients and understanding role of cyclooxygenases (COX) inhibitors in modulating anti-tumor immunity. Lymphocytes of LC patients showed decreased proliferation when stimulated with mitogens, decrease in calcium flux, low expression of activation markers and low cytotoxic response with high generation of reactive oxygen species. These lymphocytes exhibited a marked decrease in IFN- and high IL-10 with decrease in transcription factor T-bet and increased expression of GATA-3.

T-cell Acute Lymphoblastic Leukemia (T-ALL) is a clonal lymphoid malignancy. The present project aimed at determining the incidence of clonal TCR  and  junctional gene rearrangement status in Indian T-ALL patients at diagnosis and analyzing the suitability of clonal TCR  and  junctional gene rearrangement status at diagnosis as a prognostic marker for T-ALL.